Microdesmis keayana herb for sexual purposes and improvement

Microdesmis keayana J. Léonard (Pandaceae) (syn. Microdesmis puberula Hook.f. ex. Planch.) is used in African traditional medicine as a treatment for erectile dysfunction. Microdesmis keayana can stimulated nitric oxide production and thus is able to dilate blood vessels.

What's in this herb?
Microdesmis keayana root extract has xanthoquininamide (6-hydroxyquinoline-4-carboxamide) and tris(4-hydroxycinnamoyl)spermine (N(5)-(p-coumaroyl)-N(1),N(14)-diferuloylspermine) which is named keayanine and another one named keayanidine B.

Microdesmis keayana African herb for erectile dysfunction
Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction.
Phytother Res. 2008 Dec 23. Zamblé A, Martin-Nizard F, Sahpaz S, Reynaert ML, Staels B, Bordet R, Duriez P, Gressier B, Bailleul F. Zamblé A, Martin-Nizard F, Sahpaz S, Reynaert ML. Laboratoire de Pharmacognosie, E.A. 1043, Université de Lille 2, Faculté de Pharmacie B.P. 83, 59006 Lille cedex, France.
Microdesmis keayana (Pandaceae) is an African tropical plant whose roots are used in traditional medicine for erection impairment but the compounds responsible for its action are unknown. Two major alkaloids recently isolated from the roots of M. keayana, keayanidine B and keayanine, were tested for vasorelaxing properties using isolated rat aortic rings precontracted by phenylephrine to confirm its traditional use. The results showed that keayanidine B and keayanine had significant vasorelaxing properties. This effect could be due to their strong antioxidant activity. These alkaloids could indirectly stimulate nitric oxide production in the vascular bed and would explain the traditional use of Microdesmis keayana in erectile dysfunction.

Microdesmis keayana  and sexual behavior
Effects of Microdesmis keayana roots on sexual behavior of male rats.
Phytomedicine. 2007 November. Zamblé A, Sahpaz S, Brunet C, Bailleul F. Laboratoire de Pharmacognosie (E.A. 1043), Faculté de Pharmacie, Université de Lille 2, B.P. 83, 59006 Lille Cedex, France.
The aphrodisiac properties of Microdesmis keayana J. Léonard root extract and major isolated alkaloids were evaluated by observing the sexual behavior of male rats. Aqueous extract (150mg/kg body weight) and pure alkaloids (3mg/kg body weight) were administered orally by gavage to male rats. Latent times of observation, intromission and ejaculation, mounting behavior, number of intromissions and mating performances were evaluated and compared to those obtained with untreated rats in the presence of receptive and non-receptive females. The results have shown that aqueous extract and alkaloids of Microdesmis keayana stimulate sexual parameters in rats' sexual behavior. A short-term toxicity study undertaken to establish the therapeutic index of Microdesmis keayana aqueous extract showed that a high dose of the extract (2g/kg body weight) caused no mortality or changes in rats' behavior.

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